| ncRNA name | AQP4 shRNA |
| ncRNA Category | shRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas; retinal Müller cell line rMC-1 |
| Methods | shRNA knockdown, qRT-PCR, Western blot, ELISA |
| Expression pattern | associated |
| Functional description | AQP4 knockdown led to exacerbation of retinopathy including enhancing retinal vascular permeability, retinal thickness, pro-inflammatory factors expression, and VEGF and GFAP expression in retinas of diabetic rats. |
| PubMed ID | 22449442 |
| Year | 2012 |
| Title | Aquaporin 4 knockdown exacerbates streptozotocin-induced diabetic retinopathy through aggravating inflammatory response. |
| Drug-related ncRNA | NA |
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